Potential protective effect of rain tree (Albizia saman) leaf decoction on ethanol-induced hepatotoxicity in white mice (Mus musculus).

Abstract

The potential hepatoprotective effect of Albizia saman leaf decoction on ethanol-induced liver toxicity was determined. Ethanol causes the formation of reactive oxygen species (ROS) which interacts with membrane lipids that results to lipid peroxidation. A. saman or rain tree contains phytochemicals which exhibit excellent free radical scavenging activity. Liver toxicity was induced in mice for four weeks by administration of 15% ethanol. Treatment with A. saman decoction was given to three groups for four weeks in three dosages (50mg/ml, 100mg/ml and 200mg/ml). The three treatment groups showed reversal of steatosis to normal histological condition while inflammation and Kupffer cell count were reduced. Statistical analysis of A. saman treatments showed to have improved the hepatic health of ethanol-exposed mice based on steatosis, inflammation, and Kupffer cell count in a non-dosage dependent manner by providing exogenous antioxidants such as tannins, flavonoids, and lupeol that balance the increase in ROS during chronic alcohol consumption. A. saman decoction, is a potential antioxidant therapeutic intervention in ethanol-induced liver toxicity.