Abstract:
Petunidin-3-glucoside (P3G) is an anthocyanin that can be found in vegetables,
fruits, and wine. Anthocyanins are capable of reducing oxidative stress through their
free-radical scavenging capacity, which can be attributed to their ring orientation.
However, P3G remains to be understudied in vivo, particularly in Drosophila
melanogaster models. Thus, this study tested the effects of P3G on the lifespan and motor
function of D. melanogaster under the absence and presence of stress conditions, namely
chronic exposure to sublethal concentrations of alcohol and glyphosate. In groups without
stress, only 12.5 μg/ml concentration of P3G exhibited positive significant effects on the
lifespan of D. melanogaster, while higher concentrations observed no significant
difference from the control. Additionally, in the presence of chronic alcohol exposure,
only 50 μg/ml concentration of P3G exhibited positive significant effects on the lifespan
of D. melanogaster, while lower concentrations observed no significant difference from
the control. However, P3G did not result in any significant effect on D. melanogaster
under chronic glyphosate exposure. In terms of geotactic activity of D. melanogaster,
P3G supplementation did not result in any significant effect under the absence and
presence of stress conditions. In conclusion, P3G is likely to extend the lifespan of D.
melanogaster without stress only at low concentrations and is likely to mitigate the
neurotoxic effects of alcohol over glyphosate.
