Effects of xanthone glycoside from Peperomia pellucida (l.) Kunth against hyperglycemia and alterations in pancreas of HFD/Stzinduced diabetic mice Mus musculus

Abstract

Type II diabetes mellitus (T2DM) known to be the most prevalent form of diabetes, is caused by defects in insulin secretion, decreased sensitivity of insulin target cells, and ß-cell dysfunction. This study tests the effects of xanthone glycoside from Peperomia pellucida on blood glucose levels and pancreas histology of HFD/STZ- induced diabetic Mus musculus. The experiment used 30 mice divided equally into 6 groups. Two groups served as the negative and positive control, while the remaining 4 groups were administered with metformin, 10 mg/kg xanthone glycoside, 20 mg/kg xanthone glycoside, and 40 mg/kg xanthone glycoside. Body weight, blood glucose, islet diameter, and pancreas histology were obtained and analyzed. Results indicate that 20 mg/kg xanthone glycoside from P. pellucida significantly lowered blood glucose levels and can reduce alterations in pancreatic histology of HFD/STZ induced diabetic Mus musculus.