Please use this identifier to cite or link to this item: http://dspace.cas.upm.edu.ph:8080/xmlui/handle/123456789/195
Title: Hepatoprotective effect of Moringa oleifera Lam. ethanolic leaf extract on alcohol-induced liver damage in mice.
Authors: Gordola, Alinda Mae C.
Marquez, Jubert C.
Keywords: Moringa oleifera
Hepatoprotective effect
Histopathological analysis
AntiFibrotic effect
Issue Date: Mar-2012
Abstract: The study aimed to evaluate the hepatoprotective effect of ethanolic Moringa oleifera leaf extract on alcohol-induced liver damage in mice by histopathological analysis of the following parameters: steatosis, inflammation, necrosis, fibrosis and the percentage of apoptotic index. Four groups of 12 male mice each were subjected to different treatments for 8 weeks. Group 1, the control group, was provided with commercial pellet and water. Group 2, the negative control group, received commercial pellet and 15% ethanol as liquid source. Groups 3 and 4, the experimental groups, were given commercial pellet mixed with 400 mg/kg<sub>bw</sub>/d and 800 mg/kgbw /d of ethanolic M. oleifera leaf extract, respectively, and 15% ethanol as liquid source. Treatment with the extract at 400 mg/kg<sub>bw</sub> decreased steatosis and necrosis in Group 3. Inflammation, although not statistically significant, was also reduced in the said group. Group 4, on the other hand, exhibited significantly enhanced steatosis, necrosis and inflammation as Group 2. Fibrosis and the percentage of apoptotic index were not significantly different among the groups. It can be inferred that the ethanolic M. oleifera leaf extract has a significant hepatoprotective effect at the dose of 400 mg/kg<sub>bw</sub>/d. This may be due to the antioxidants present in the said extract. The effect of the extract is, however, not dose-dependent. This could be a result of an oversupply of antioxidants. Antioxidants, when present in excess, can act as prooxidants, and promote oxidative stress.
URI: http://cas.upm.edu.ph:8080/xmlui/handle/123456789/195
Appears in Collections:BS Biology Theses

Files in This Item:
File Description SizeFormat 
CD-C26.pdf
  Until 9999-01-01
C26.pdf2.15 MBAdobe PDFView/Open Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.