Effect of acute exposure to different concentrations of bisphenola-A on the gonads of sexually mature male zebrafish (Danio rerio) and early life stafe development in progeny.

Abstract

Aquatic species are often exposed to endocrine disrupting chemicals such as Bisphenol-A (BPA) due to massive dumping of garbage in aquatic bodies. The main goal of the study is to determine the effects of BPA, an endocrine disruptor found in plastics and epoxy resins, on the testis of male zebrafish and its progeny. The male fish were exposed to 0 µg/L, 20 µg/L, 200 µg/L and 2,000 µg/L of BPA and were subsequently mated with nonexposed females. The development of their offspring at different embryological stages (24 h, 48 h, and 72 h) was observed. Results show that BPA has an effect on the gonads of sexually mature male zebrafish indicated by changes in testis histology, specifically observed in zebrafish exposed to 2,000 µg/L. No paternal transmission of adverse effects of BPA was observed in the 0, 20, 200 and 2,000 µg/L BPA set-ups.