Abstract:
The purpose of the study is to investigate if administration of human
and carabao milk have radioprotective effect on polychromatic
erythrocytes by inhibiting micronucleus formation. It seeks to
compare the effects of the two milk types on polychromatic
erythrocytes of irradiated mice. Twenty male, albino mice were
treated with carabao milk for four weeks and were irradiated at 1, 2,
3, 4 and 5 Grays. Another set of twenty was given human milk and
was irradiated. Four mice not given any milk nor irradiated were
designated as baseline group while four mice not given milk but was
irradiated at 5 Gray was assigned as control group. The
micronucleus test was used to determine the radioprotective
potential of the two milks. Bone marrow smears were examined to
determine the frequency of micronucleated polychromatic
erythrocytes per 1000 cells. Data gathered was analyzed using oneway
analysis of variance (ANOVA). Multiple comparisons were
employed to detect significant differences among groups. The
control group has highest micronucleus frequency (4.325%) while
the baseline group has the lowest micronucleus frequency (1.3%).
The study showed that administration of either human or carabao
milk has a radioprotective effect on the polychromatic erythrocytes
of mice irradiated at 1 to 3 Grays. Statistical analysis revealed that
carabao and human milk have no significant difference in their
radioprotective potential.
