Effects of Cyclooxygenase Inhibitors on the Radiation Response of Intestinal Crypt Cells in Male Mice

Dones, Rosa Angela SA.; Serna, Paulene-Ver A.

dc.contributor.author	Dones, Rosa Angela SA.
dc.contributor.author	Serna, Paulene-Ver A.
dc.date.accessioned	2026-03-13T03:00:17Z
dc.date.available	2026-03-13T03:00:17Z
dc.date.issued	2002-03
dc.identifier.uri	http://dspace.cas.upm.edu.ph:8080/xmlui/handle/123456789/3582
dc.description.abstract	The effects of varying doses of different types of Cyclooxygenase (COX) inhibitors on irradiated and nonirradiated murine intestinal crypt cells were investigated. Cell counts, supported by data from TUNEL assay and immunohistochemical analyses, revealed that apoptosis was greatest in irradiated tissues treated with NSAIDS. Irradiated cells treated with COX-2 inhibitors showed least occurrence of apoptosis with increased occurrence of regenerating cells. Results suggest a potential role of COX- 2 selective inhibitors as a radioprotective agent for normal cells in radiation therapy.	en_US
dc.subject	cyclooxygenase	en_US
dc.subject	COX inhibitors	en_US
dc.subject	radiation	en_US
dc.subject	intestinal crypt cells	en_US
dc.subject	regenerating cells	en_US
dc.subject	radioprotective agent	en_US
dc.title	Effects of Cyclooxygenase Inhibitors on the Radiation Response of Intestinal Crypt Cells in Male Mice	en_US
dc.type	Thesis	en_US