The Radioprotective Potential of Carabao Milk and Human Milk on Irradiated Mice (Mus Musculus L.)

Abstract

The purpose of the study is to investigate if administration of human and carabao milk have radioprotective effect on polychromatic erythrocytes by inhibiting micronucleus formation. It seeks to compare the effects of the two milk types on polychromatic erythrocytes of irradiated mice. Twenty male, albino mice were treated with carabao milk for four weeks and were irradiated at 1, 2, 3, 4 and 5 Grays. Another set of twenty was given human milk and was irradiated. Four mice not given any milk nor irradiated were designated as baseline group while four mice not given milk but was irradiated at 5 Gray was assigned as control group. The micronucleus test was used to determine the radioprotective potential of the two milks. Bone marrow smears were examined to determine the frequency of micronucleated polychromatic erythrocytes per 1000 cells. Data gathered was analyzed using oneway analysis of variance (ANOVA). Multiple comparisons were employed to detect significant differences among groups. The control group has highest micronucleus frequency (4.325%) while the baseline group has the lowest micronucleus frequency (1.3%). The study showed that administration of either human or carabao milk has a radioprotective effect on the polychromatic erythrocytes of mice irradiated at 1 to 3 Grays. Statistical analysis revealed that carabao and human milk have no significant difference in their radioprotective potential.